Research Groups
Medical Microbiology and Clinical Trials
Dr. Bui Tien Sy, MD, PhD (in Germany)
Our research group specializes in the detection and identification of microbial pathogens, with a particular focus on phenotypic and genotypic resistance patterns. Our goal is to develop innovative methods for pathogen detection and to deepen our understanding of antibiotic resistance mechanisms in bacteria through next-generation sequencing (NGS) technologies, including Illumina and Nanopore sequencing. Additionally, we explore rapid antibiogram testing methods and novel approaches to combat bacterial resistance, such as bacteriophage therapy. Beyond bacterial resistance, our research extends to viral and parasitic infections. One of our key projects, “Clinical Significance and Molecular Characterization of Hepatitis E and Hepatitis D Virus Infections in High-Risk Populations in Vietnam,” is conducted within the framework of the Vietnamese-German bilateral research collaboration.
Access Dr. Bui Tien Sy CV here
Host-Pathogen Interactions in Infectious Diseases
Assoc. Prof. Dr. Hoang Van Tong, PhD (in Germany)
Our research group investigates the potential associations and functional interactions between host factors - including human genetics, immune responses and epigenetics - and infectious pathogens. We primarily focus on hepatitis B, D, and E viruses and their role in liver diseases such as liver cirrhosis and hepatocellular carcinoma. Specifically, we study the functional roles of signaling pathways (JAK/STAT/SOCS), interferon-stimulated genes, and ISGylation in hepatitis B-related liver diseases. Additionally, we explore the roles of the complement system and non-coding RNAs (lncRNAs and miRNAs) in Dengue infection. Our work also encompasses the molecular epidemiology and clinical impact of hepatitis virus infections and co-infections. Beyond viral research, we investigate bloodstream and parasitic infections (e.g. malaria) and develop advanced diagnostic tools for infectious disease detection and identification.
Access Prof. Dr. Hoang Van Tong CV here.
Viral Hepatitis and Related Liver-Diseases, Advanced Molecular Biomarkers and Metabolomics in Cancers
Dr. Nghiem Xuan Hoan, MD, PhD (in Germany)
Our research focuses on viral hepatitis and chronic liver diseases, with expertise in the molecular epidemiology of HBV, HDV, and HEV, as well as genetic and epigenetic factors influencing HBV-related liver disease progression. Currently, we aim to develop novel biomarkers using a multimodal approach (genomics, metabolomics, and immunomics) for early cancer detection, particularly liver cancer. Additionally, we explore molecular pathology and targeted therapies for liver diseases and oncology. Through our work, we strive to improve patient care, enhance patient outcomes and advance precision medicine.
Infectious Diseases, Sepsis and Septic Shock, Antimicrobial Resistance, Clinical Trials
Dr. Trong Nguyen The, MD, PhD (in Germany)
Our research group focuses on conducting ICH-GCP/GCLP-compliant phase I-IV clinical trials and clinical research on dengue hemorrhagic fever, malaria, sepsis, meningitis and various severe infectious diseases. Dr The is also head of the Intensive Care Unit (ICU) for infectious diseases. Various clinical trials have been conducted in our research group, e.g. on antimalarials, therapeutics for dengue fever and COVID-19 vaccines.
Access Dr. Trong Nguyen The CV here
Application of Advanced Molecular Methodologies in Infectious Diseases and Antimicrobial Resistance
Dr. Truong Nhat My, PhD (in France)
Our research themes focus on using innovative biomolecular techniques to enhance diagnostics and treatments for infectious diseases and combat antimicrobial resistance (AMR). Key areas include molecular diagnostics, genomic surveillance, and understanding resistance mechanisms. This multidisciplinary approach aims to develop new methods and inform public health policies. Ultimately, it addresses the urgent challenges posed by AMR in global health.
Access Dr. Truong Nhat My CV here
Cell Signaling and Cancer Therapy
Assoc. Prof. Dr. Bui Khac Cuong, MD, PhD (in Germany)
Our research group explores oncogenic mechanisms and develops targeted therapies in preclinical models to advance precision cancer treatment. We employ advanced techniques, including PCR, qRT-PCR, droplet digital PCR, ELISA, IF, IHC, FACS, Western blot, and gene editing (siRNA, shRNA, CRISPR/Cas). To investigate tumorigenesis and evaluate novel therapeutics, we conduct cell-based experiments and establish animal models to bridge in vitro studies with clinical applications. Our current focus areas include metabolic regulation and DNA damage repair in cancer therapy, recombinant protein and antibody synthesis, and CAR-T cell development. We collaborate closely with international partners in Germany, South Korea, and the USA.
Access Dr. Bui Khac Cuong CV here.
Antimicrobial Resistances and Diagnostics
Dr. Ngo Tat Trung, PhD (in Germany)
Rapid diagnosis is crucial for timely and effective interventions in patients suffering from meningitis, sepsis and/or other acute infectious syndromes. Our research focuses on translating synthetic gene networks and synthetic biology into paper-based diagnostic prototype devices for detecting acute infectious pathogens. We aim to address multiple infectious conditions, including bloodstream infections, tuberculosis, influenza, and meningitis, with a particular emphasis on resource-limited settings in low- and middle- income countries such as Vietnam. Additionally, our team is dedicated to cancer diagnosis and treatment, with a strong focus on liver cancer. We strive to implement reliable and effective strategies for early detection and population screening to significantly improve patient survival rates through timely interventions.
Access Dr. Ngo Tat Trung CV here
Medical Oncology, Clinical Trials and Precise Oncology
Dr. Truong Huu Hoang, PhD (in Japan)
The primary mission of our research team is to advance personalized oncology by developing projects focused on individualized cancer treatment. This includes establishing and refining 3D organoid cancer tissue culture techniques, as well as implementing clinical trials for novel targeted therapies guided by comprehensive gene mutation analyses via Next Generation Sequencing (NGS) technology in metastatic cancer patients (also known as precision oncology). Our team also actively participates in multicenter clinical trials involving new therapeutic agents. Additionally, we investigate cancer pathogenesis mechanisms and identify novel biomarkers that could impact therapeutic efficacy, particularly in response to chemotherapy, targeted therapies, and immunotherapies, aiming to elevate treatment standards and outcomes.
Access Dr. Truong Huu Hoang CV here
Neuroscience, Molecular Neurology and Rehabilitation
Dr. Nguyen Quang Linh, MD, (PhD in Japan)
Our research explores the pathological mechanisms of stroke and neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson’s, and Alzheimer’s disease, by using disease models based on genetic factors. Additionally, we investigate therapeutic strategies to improve neurological treatment outcomes through stem cell technology, artificial intelligence, and rehabilitation techniques. Our goal is to reduce disease burden and enhance patients’ quality of life.
Access Dr. Nguyen Quang Linh CV here
